Lipocortin Output by Human Endometrium in Vitro*

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Abstract
Lipocortin was found to be secreted by human endometrium incubated for 1–2 days under organ culture conditions. Levels of lipocortin in the culture medium, measured by RIA, were increased by dexamethasone (10-8–10-6 M) and decreasedby progesterone (10-8-l0-6 M). Both steroids, however, decreased prostaglandin F2α (PGF2α) output, also estimated by RIA. These results suggest that lipocortin does not mediate the inhibition of PGF2α production evoked by progesterone. Dexamethasone may inhibit PGF2α production by mechanisms involved in the inhibition by progesterone in addition to those mediated by an elevation in thelevels of lipocortin, a phospholipase inhibitor.