Pharmacokinetic parameters for thallium (I)-ions in man
- 1 May 1983
- journal article
- research article
- Published by Springer Nature in Archives of Toxicology
- Vol. 53 (1) , 1-7
- https://doi.org/10.1007/bf01459996
Abstract
The pharmacokinetics of Tl+ were studied in 9 patients who underwent myocardial scintigraphy with201Tl+. The time course of the201Tl+ concentration fitted to an open two-compartment model. The following values were calculated:k12=0.164±0.025 min−1,k21=0.011 ± 0.004 min−1,k10=0.005±0.004 min−1,t1/2(κ1)=3.92±0.54 min, t1/2(λ2)= 3108±896 min,CL=0.08±0.03 l/min,V1=0.26±0.13 I/kg,V z =4.36 ± 0.65 l/kg,V ss =4.23±0.67 l/kg. Using previously published dialysance values the influence of hemodialysis on Tl+ elimination was calculated. Hemodialysis in Tl+ intoxications should be moderately effective.Keywords
This publication has 18 references indexed in Scilit:
- The excretion of thallium (I)-ions into the gastrointestinal tract in situ of ratsArchives of Toxicology, 1982
- Symbols in pharmacokineticsJournal of Pharmacokinetics and Biopharmaceutics, 1980
- Thallium-201 myocardial scintigraphy in acute myocardial infarction and ischemiaSeminars in Nuclear Medicine, 1980
- Thallium Intoxication Treated with Long‐term Hemodialysis, Forced Diuresis and Prussian BlueActa Medica Scandinavica, 1978
- Verlaufskontrolle der Intensivtherapie von ThalliumintoxikationenArchives of Toxicology, 1977
- Thallium-201 as a myocardial imaging agentSeminars in Nuclear Medicine, 1977
- Thallium Intoxication Treated With Dithizone and HemodialysisArchives of internal medicine (1960), 1972
- Behandlung der Thalliumvergiftung mit der HämodialyseDeutsche Medizinische Wochenschrift (1946), 1971
- A Method for Minimizing a Sum of Squares of Non-Linear Functions Without Calculating DerivativesThe Computer Journal, 1965
- Distribution of Thallium in the Organism and its Elimination.Acta Pharmacologica et Toxicologica, 1956