EVALUATION OF NEUROGENIC CONTROL OF BLOOD PRESSURE IN HYPERTENSION WITH TETRAETHYLAMMONIUM CHLORIDE AND SPINAL ANESTHESIA 1

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Abstract
Observations and comparisons of the blood pressure responses to autonomic blockade with tetraethylammonium chloride (TEAC) and spinal anesthesia to high thoracic levels were made in 11 malignant and 13 benign hypertensives. In all patients the blood pressure was reduced significantly by both TEAC and spinal anesthesia. There was a clear parallelism between the degree of blood pressure fall to the 2 procedures, and the blood pressure floors achieved by TEAC were slightly but significantly lower than the floors obtained with spinal anesthesia ranging from T6 to T3. The level of the blood pressure tended to vary indirectly with the level of spinal anesthesia. It was further demonstrated that TEAC, when administered during high spinal anesthesia, causes a further reduction in blood pressure. This provides additional evidence that the autonomic block induced by TEAC is relatively more complete than that which occurs with extensive but anatomically incomplete spinal anesthesia.