EFFECTS OF LOCAL-ANESTHETICS ON PHORBOL ESTER - INDUCED ORNITHINE DECARBOXYLASE ACTIVITY IN MOUSE AND HUMAN-SKIN
- 1 January 1984
- journal article
- research article
- Vol. 4 (6) , 363-366
Abstract
In preparation for experiments to determine the effects of various orally administered tumor promoters and antipromoters on human skin ornithine decarboxylase (ODC) activity, it was observed that intradermal lidocaine hydrochloride inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ODC. Topically applied ethyl chloride had variable and unpredictable effects on ODC induction. Adequate local anesthesia can be obtained by using intradermal 1.0% procaine hydrochloride or normal saline; neither of these agents inhibited TPA induction of epidermal ODC activity in incubated human skin punch biopsies.This publication has 6 references indexed in Scilit:
- Local anesthetics inhibit induction of ornithine decarboxylase by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate.Proceedings of the National Academy of Sciences, 1980
- An organ culture of adult mouse skin: An in vitro model for studying the molecular mechanism of skin tumor promotionBiochemical and Biophysical Research Communications, 1980
- INDUCTION OF MOUSE EPIDERMAL ORNITHINE DECARBOXYLASE ACTIVITY AND DNA-SYNTHESIS BY ULTRAVIOLET-LIGHT1979
- CORRELATION OF THE INHIBITION BY RETINOIDS OF TUMOR PROMOTER-INDUCED MOUSE EPIDERMAL ORNITHINE DECARBOXYLASE ACTIVITY AND OF SKIN TUMOR PROMOTION1979
- VITAMIN-A ACID (RETINOIC ACID), A POTENT INHIBITOR OF 12-OMICRON-TETRADECANOYL-PHORBOL-13-ACETATE-INDUCED ORNITHINE DECARBOXYLASE ACTIVITY IN MOUSE EPIDERMIS1977
- Some Biological Aspects of Skin Carcinogenesis*Published by S. Karger AG ,1964