GELATION OF AMEBOCYTE LYSATE OF TACHYPLEUS-TRIDENTATUS BY CELL-WALL DIGEST OF SEVERAL GRAM-POSITIVE BACTERIA AND SYNTHETIC PEPTIDOGLYCAN SUBUNITS OF NATURAL AND UNNATURAL CONFIGURATIONS

1 January 1977

journal article
research article

Vol. 20 (1) , 5-10

Abstract

Water-soluble adjuvant-active fractions prepared by digestion of the cell walls from several gram-positive bacteria [Streptococcus salivarius, S. mutans, Lactobacillus plantarum] with an endo-N-acetylmuramidase (mutanolysin) gelated the amoebocyte lysate of T. tridentatus, the Japanese horseshoe crab. This finding was further extended by examination of the clotting activities on the amoebocyte lysate of a synthetic N-acetylmuramyl-L-alanyl-D-isoglutamine and related adjuvant-active or -inactive compounds, demonstrating that there are close correlations between the abilities to initiate lysate gelation, immunoadjuvancies and pyrogenicities. There are some exceptions.

This publication has 1 reference indexed in Scilit:

CORRELATION BETWEEN IMMUNOADJUVANT ACTIVITIES AND PYROGENICITIES OF SYNTHETIC N-ACETYLMURAMYL-PEPTIDES OR N-ACETYLMURAMYL-AMINO ACIDS
1976