EFFECTS OF HALOTHANE AND CHLOROFORM ON THE LIVER IN PROTEIN-DEFICIENT MICE

Open Access
Publisher Website
Google Scholar
Abstract
A single 45-minute exposure to halothane did not cause demonstrable pathological liver changes when administered to mice in an atmosphere of air or oxygen regardless of whether the diet was normal or low in protein. Similarly, increased inhaled oxygen tensions per se had no influence on liver changes. The well-known hepatotoxicity of chloroform was demonstrated in groups fed both regular and low protein diets. The animaLs tolerated the single chloroform anaesthesia less well than those receiving halo thane with significant liver damage in both groups.