Synthetic GPI array to study antitoxic malaria response
- 2 March 2008
- journal article
- Published by Springer Nature in Nature Chemical Biology
- Vol. 4 (4) , 238-240
- https://doi.org/10.1038/nchembio.75
Abstract
Parasite glycosylphosphatidylinositol (GPI) is an important toxin in malaria disease, and people living in malaria-endemic regions often produce high levels of anti-GPI antibodies. The natural anti-GPI antibody response needs to be understood to aid the design of an efficient carbohydrate-based antitoxin vaccine. We present a versatile approach based on a synthetic GPI glycan array to correlate anti-GPI antibody levels and protection from severe malaria.Keywords
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