Cyclic eosinophilic leukocytosis in eosinophilic leukemia with observations on transcobalamin I and eosinophils

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Abstract
A patient with eosinophilic leukemia was noted to have spontaneous fluctuations in his eosinophil and total leukocyte counts over a 3‐year period. The range of eosinophil counts observed was from 736/μl to 401,400/μl. Sharp fluctuations occurred whether chemotherapy was administered at the nadir or the peak of a cycle or was withheld. A shortening of the cycle length from 44 to 25 days, and a marked increase in amplitude of the cycle occurred in the terminal phase of his illness. Two additional observations merit mention. An abnormal alpha‐2 globulin of 40,000 molecular weight was detected in his serum. In addition, cyclic fluctuations of serum transcobalamin I that accompanied his cyclic eosinophil counts were noted, and eosinophils were documented for the first time to be rich sources of this protein.