Mechanism and treatment of hypertriglyceridaemia in gout.
Open Access
- 1 February 1979
- journal article
- research article
- Published by Elsevier in Annals of the Rheumatic Diseases
- Vol. 38 (1) , 31-35
- https://doi.org/10.1136/ard.38.1.31
Abstract
Using the Intralipid lipid tolerance test we could not demonstrate any direct effect of serum triglyceride on uric acid or any influence of hyperuricaemia on triglyceride removal. This result supports previous studies suggesting that hyperuricaemia and hypertriglyceridaemia are linked through the association of obesity and alcohol excess rather than a direct cause and effect mechanism. It was possible to demonstrate significant reductions of serum triglyceride in patients with gout by reducing either their alcohol intake or body weight. Reduction of serum uric acid by probenecid had no effect on serum triglyceride or cholesterol. Similarly, allopurinol had no significant effect on serum triglyceride, but a significant fall of serum cholesterol was observed.Keywords
This publication has 37 references indexed in Scilit:
- HYPERTRIGLYCERIDqMIA AND HYPERURICqMIAThe Lancet, 1977
- Epidemiology of serum uric acid among 8000 Japanese-American men in HawaiiJournal of Chronic Diseases, 1977
- The effect of hypolipidaemic therapy on serum uric acid concentrationAtherosclerosis, 1976
- Intralipid triglyceride and oral glucose toleranceDiabetologia, 1974
- Familial hyperuricaemia and hypertriglyceridaemia.Annals of the Rheumatic Diseases, 1973
- Alteration of Urate Metabolism by Weight ReductionAustralian and New Zealand Journal of Medicine, 1973
- Determination of the intravenous fat tolerance test with intralipid® by nephelometryAtherosclerosis, 1972
- Hyperlipoproteinaemia in gout.Annals of the Rheumatic Diseases, 1971
- Effect of atromid and its components on uric acid excretion and on gout.Annals of the Rheumatic Diseases, 1965
- Hypertriglyceridemia in GoutCirculation, 1964