Suppression of Friend Virus-induced Leukaemia in Mice by Tuftsin

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Abstract
A significant decrease in mortality was observed when 25 .mu.g of the tetrapeptide tuftsin was given to DBA/2J mice 5 days before infection with Friend leukemia virus (FLV). The same effect was observed when tuftsin was given 5 days before and twice a week for 3 weeks after FLV infection. No effect was observed when the same amount of tuftsin was given 1 day before infection. A 5 .mu.g dose of tuftsin given 5 days before and twice-wekly for 3 weeks had no effect on leukaemia induced by FLV infection. These findings showed that time and dosage were critical to the protective effect of tuftsin against virus-induced leukaemia.