Inhibition by Tuftsin of Rauscher Virus Leukemia Development in Mice2
- 1 July 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 71 (1) , 87-90
- https://doi.org/10.1093/jnci/71.1.87
Abstract
The antitumor effect of tuftsin, the natural phagocytosis-stimulating peptide, on leukemia induced by Rauscher murine leukemia virus (R-MuLV) was studied in vivo in SWR inbred mice. Tuftsin was found capable of significantly increasing the survival of R-MuLV-infected mice. The peptide, when injected both ip and iv into mice, exerted its activity in a dose- and time-dependent manner. Optimal antitumor activity was achieved upon administration of 25 μg tuftsin 4 days before R-MuLV inoculation.Keywords
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