THE HORMONE CONTROL OF OVULATION IN THE CALF

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Abstract
CASIDA et al. (1943) demonstrated that follicular development could be stimulated in the ovaries of the immature calf by treatment with anterior pituitary extracts. It was therefore thought possible that further investigation might offer a practical method of obtaining a supply of cow ova for further experimentation. METHODS Heifer calves of varying ages were injected subcutaneously twice daily with an anterior pituitary extract high in F.S.H. (follicular stimulating hormone). This treatment was continued from 72 to 96 hours after which an interval of 48 hours was allowed when the animals were intravenously injected with human chorionic gonadotrophin or pituitary extracts high in L.H. (Luteinising Hormone). The animals were killed 72 hours after the intravenous injection. RESULTS The results almost immediately indicated a great predominance of follicular development over luteinisation (Fig. 1). However, one or more ovulations were observed in 55% of the animals treated though the number of ovulated or luteinised follicles was always greatly inferior

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