INTUBATION STUDIES OF THE HUMAN SMALL INTESTINE. XXII. AN IMPROVED TECHNIC FOR THE STUDY OF ABSORPTION; ITS APPLICATION TO ASCORBIC ACID

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Abstract
Employing a modification of the Miller-Abbott technic for intestinal intubation, a method is described for the quantitative investigation of absorption from the small intestine. The advantages over other methods are listed: the motor and secretory functions of the bowel are not disturbed; all mechanical obstruction is avoided; the conc. of the soln. may be kept within normal range for the specific segment of bowel; the rate of perfusion may be normal, and a sharp point for the termination of the expt. is provided. Application of the procedure to glucose demonstrated the completeness with which the expt. could be terminated. Its application to ascorbic acid showed that within a 45 cm. loop of intestine an amt. of the vit. far in excels of the daily optimal requirement for man could readily be absorbed.