ENDOCRINE INFLUENCES ON RENAL COMPENSATORY HYPERTROPHY1

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Abstract
The percentage of renal compensatory hypertrophy seen 25 days after uninephrectomy (30.9) in rats that had been hypo-physectomized 30 days before uninephrectomy was the same as in normal rats (34.7). When an interval of 107-153 days was allowed between hypophysectomy and uninephrectomy, the percentage of hypertrophy seen 25 days after uninephrectomy was significantly lower (24.5). With 3 groups of rats, treatment with growth hormone, with thyroxin, and with growth hormone plus thyroxin, was begun at the time of uninephrectomy (30 days after hypophysectomy). No convincing evidence was obtained that any of these treatments resulted in 25-day postnephrectomy hypertrophy different from that observed in untreated rats which had been hypophysectomized 30 days before uninephrectomy.