The oxidation of various precursors in normal and tumour-bearing mice in vivo

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Abstract
The extent to which a developing neoplasm such as Ehrlich solid tumor affects the oxidation of selected precursors to CO2 was studied. Studies of expiratory 14CO2 in vivo demonstrated that a tumor mass as small as 0-5% of the total body weight has an effect on the oxidative patterns of [14C]acetate in comparison with control mice. This suggests that the tumor may exert a systematic effect on general body metabolism. The decreased rate of production of 14CO2 from [1-14C]acetate and of [2-14C]leucine was inversely proportional to the increase in tumor size in mice bearing Ehrlich solid tumors. [2-14C]-Acetate did not show the same difference in the production of 14CO2. The importance of the hexose monophosphate oxidative pathway in mice bearing Ehrlich solid tumors was demonstrated by the greater rate of release of 14CO2 from [I-14c]glucose than from [6-14c]glucose. Comparable studies of patterns of expired 14CO2 on mice with lymphatic leukemia failed to show similar changes.