Comparison of dye-dilution and flowmeter estimates of pulmonary valve incompetence in dogs

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Abstract
Quantitative estimates of backflow were obtained in dogs with experimental pulmonary valve incompetence by means of a bristle flowmeter and the dye curve variance method. The variance of the curve was found to be the best index of indicator dispersion and is calculated from analogy to a frequency distribution curve. The method postulates that (forward flow + backflow)/forward flow = variance observed during incompetence/Vx(F; V), where Vx(F; V) is the expected variance for the same forward flow and volume between injection and sampling sites and is determined from regression equations calculated from data of normal dogs. There was good agreement between dye and flowmeter results, provided that Vx(F2;V) was estimated for the specific regression equations obtained from individual dogs. Three or four successive dye curves, obtained while the animal was in a steady state, permitted quantitation of backflow with the accuracy of a single determination of forward flow by the direct Fick or dye method. When Vx(F;V) was estimated from regression equations obtained from the pooled data and normal dogs, agreement with the flowmeter estimates was poor. Submitted on October 28, 1959