MEASUREMENT OF THYROID HORMONE IN EXPERIMENTAL THYROID TUMOURS IN RATS
- 1 November 1977
- journal article
- research article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 75 (2) , 245-250
- https://doi.org/10.1677/joe.0.0750245
Abstract
Rats treated with 131I and propylthiouracil were shown to develop thyroid tumours 7–9 months after treatment. In this group, the levels of total thyroxine and tri-iodothyronine, and free thyroxine and tri-iodothyronine in the serum were low, and that of TSH was raised. In a group of rats treated with 131I and then propylthiouracil and thyroxine, thyroid tumours were found despite normal concentrations of total and free thyroxine and tri-iodothyronine in the serum. The level of TSH in the serum was significantly raised in this group. Thyroid tumours were not found in the various control groups of rats.This publication has 3 references indexed in Scilit:
- Determination of the Free Thyroxine Content of SerumJournal of Clinical Endocrinology & Metabolism, 1964
- INFLUENCE OF PROPYLTHIOURACIL ON THE THYROXINE-THYROTROPIN INTERPLAY1Endocrinology, 1960
- OBSERVATIONS ON THE PRODUCTION OF GOITER IN RATS WITH PROPYLTHIOURACIL ANDON GOITER PREVENTION1Endocrinology, 1959