Sex and Genetic Differences in the Elimination of Sulphadimidine in Rats

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Abstract
Rats of five inbred strains and two random-bred stocks were intravenously given sulphadimidine (40 mg/kg body weight). A relatively low percentage of acetylsulphadimidine (Ac-S) in urine and absence of strain differences were found in males, whereas two phenotypes can be distinguished in females: (1) high percentage of Ac-S in urine, and (2) low percentage of Ac-S in urine. An autosomal control of these differences is suggested. A dominant allele which determines the high percentage of excreted Ac-S manifests itself only in female endo-environment.