The nigrostriatal dopaminergic system in familial early onset parkinsonism with parkin mutations
- 26 June 2001
- journal article
- Published by Wolters Kluwer Health in Neurology
- Vol. 56 (12) , 1759-1762
- https://doi.org/10.1212/wnl.56.12.1759
Abstract
Nigrostriatal dopaminergic function and cerebral energy metabolism were measured with PET in two brothers with early-onset parkinsonism caused by mutation of the parkin gene. Energy metabolism did not differ, but the nigrostriatal dopaminergic pattern was clearly different than that of sporadic PD. Thus parkinsonism in these two patients was shown to be pathophysiologically different than PD.Keywords
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