A STUDY ON SPERMATOGENESIS IN RATS

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Abstract
Testosterone propionate (TP), pregnant mare serum hormone (PMS) and a hypophyseal synergist were administered to rats hypophysectomized between the ages of 25-44 days. Both gonadotrophic substances induced distinct seminiferous tubular development in rats regardless of age. Androgen, however, brought about sperm formation only in animals hypophysectomized on or after day 29; tubular development was greater as age increased. Large numbers of germinal elements desquamated from the testicular tubules were found in the epididymides of TP-treated, but not of gonadotrophin-treated, rats. Tubular damage is discussed in the light of spermatogenic sloughing, and the possibility that androgen influences transport of germinal cells from testis to epididymis is suggested.

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