Influence of L-Norepinephrine Upon Cardiac Output in Anesthetized Dogs

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Abstract
It was the purpose of this investigation to test again the general conclusion that norepinephrine augments cardiac output during experimental hemorrhagic hypotension but has no such effect on normal animals or man. Results are presented which fail to support this differential action in normal and hypotensive dogs and an explanation is offered for failure of the drug to increase cardiac output in human subjects.