Priming virulence factors for delivery into the host
- 1 September 2003
- journal article
- Published by Springer Nature in Nature Reviews Molecular Cell Biology
- Vol. 4 (9) , 738-744
- https://doi.org/10.1038/nrm1201
Abstract
Several medically important Gram-negative bacterial pathogens inject virulence factors into host cells through a type III secretion system and specialized bacterial chaperones are required for their effective delivery. Recent structural work shows that these chaperones maintain virulence factors in a partially non-globular conformation that is primed for unfolding and translocation through the 'injectisome'.Keywords
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