Size of the intracellular circular Epstein-Barr virus DNA molecules in infectious mononucleosis-derived human lymphoid cell lines

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Abstract
The size of non-integrated circular Epstein-Barr virus (EBV) DNA molecules isolated from 7 different human lymphoblastoid cell lines of infectious mononucleosis origin was determined by sedimentation analysis and by direct contour length measurements on electron micrographs. Six lines had intracellular circular EBV genomes of the same size as linear virion DNA molecules. The 7th line, established with the B95-8 strains of EBV, was the only one found to have circular EBV DNA molecules significantly smaller than virion DNA. Intracellular EBV DNA circles of reduced size do not generally occur in infectious mononucleosis-derived cell lines.