INTRAVITREAL INJECTION OF VANCOMYCIN IN EXPERIMENTAL STAPHYLOCOCCAL ENDOPHTHALMITIS
- 1 June 1975
- journal article
- clinical trial
- Published by Wiley in Acta Ophthalmologica
- Vol. 53 (3) , 311-320
- https://doi.org/10.1111/j.1755-3768.1975.tb01162.x
Abstract
Toxicity, clearance, and therapeutic effectiveness of intravitreal vancomycin hydrochloride injection in experimentally induced staphylococcal endophthalmitis were evaluated. Vancomycin was found to be nontoxic in a single, 1 mg/0.1 ml intravitreal dose. Therapeutic levels of vancomycin were present in the vitreous for over 72 hours and in the aqueous during a period from 6 to 48 hours after injection. Injection of a methicillin-resistant Staphylococcus aureus produced a panophthalmitis in our systemically treated controls, whereas in the rabbits treated by intraocular injection, the course of the infection was significantly altered.Keywords
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