REVIEW: The Application of Dendritic Cell-derived Exosomes in Tumour Immunotherapy
- 1 April 2000
- journal article
- review article
- Published by Mary Ann Liebert Inc in Cancer Biotherapy & Radiopharmaceuticals
- Vol. 15 (2) , 185-194
- https://doi.org/10.1089/cbr.2000.15.185
Abstract
Cancer arises from the aberrant proliferation of a single transformed cell. This population acquires the ability to metastasise. An effective way to remove cancer cells from the body is to activate tumour-specific cytotoxic T cells (CTL). Activation of naive T cells depends on the unique antigen presenting capacity of DC. Activated tumour antigen-specific CTL can destroy cancer cells without harm to normal tissue. Their ability to stimulate antigen specific T cell responses makes DC attractive candidates to potentiate anti-tumour immunity. Several studies have demonstrated the efficacy of DC based anti-tumour immunotherapy and the goal now is to optimise immune responses induced by DC, so that effective strategies in treating cancer may be realised. One way to do this is to identify DC characteristics which make them more effective in T cell stimulation. Another is to use exosomes, the antigen presenting vesicles secreted by DC, in order to induce potent anti-tumour immune responses. The non-cellular nature of exosomes offers several advantages for use in tumour immunotherapy.Keywords
This publication has 34 references indexed in Scilit:
- Tumour surveillance: Missing peptides and MHC moleculesImmunology & Cell Biology, 1998
- MHC Class I–Restricted CTL Responses to Exogenous AntigensImmunity, 1996
- Association Between HLA-DM and HLA-DR In VivoImmunity, 1996
- Therapy of murine tumors with tumor peptide-pulsed dendritic cells: dependence on T cells, B7 costimulation, and T helper cell 1-associated cytokines.The Journal of Experimental Medicine, 1996
- Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re‐filling of the lytic granules and secretion of lytic proteins via a non‐granule pathwayEuropean Journal of Immunology, 1995
- Assembly, Transport, and Function of MHC Class II MoleculesAnnual Review of Immunology, 1994
- Signals and signs for lymphocyte responsesCell, 1994
- Lymphocyte responses and cytokinesCell, 1994
- Assembly and Intracellular Transport of MHC Class I MoleculesAnnual Review of Cell Biology, 1993
- Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartmentsNature, 1991