Expression of human placental‐type alkaline phosphatase in primary breast cancer
- 15 August 1983
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 32 (2) , 205-209
- https://doi.org/10.1002/ijc.2910320211
Abstract
A monoclonal antibody (H317) with specificity for the heat‐stable placental‐type alkaline phosphatase (Pl‐ALP) isoenzyme has been used to investigate the occurrence of Pl‐ALP in patients with primary breast carcinoma. All pre‐operative plasma samples were negtive for Pl‐ALP in a sensitive solid‐phase enzyme immunoassay with a lower limit of detection of 0.1 U/I. In contrast, using a peroxidase‐anti‐peroxidase staining technique on fixed tissue sections, as well as enzyme immunoassay on fresh tissue extracts, Pl‐ALP could be demonstrated in the carcinomatous tissue of all seven patients investigated.This publication has 23 references indexed in Scilit:
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