INFLUENCE OF SULPHONAMIDES ON FIBROBLASTS
- 1 June 1945
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Research
- Vol. 23e (3) , 80-84
- https://doi.org/10.1139/cjr45e-010
Abstract
The toxicity of several sulphonamides for tissue cells has been tested by adding the compounds to tissue cultures of fibroblasts (guinea pig heart tissue in guinea pig serum). Supersaturated solutions of sulphadiazine or sulphapyrazine, in serum, have no influence on the growth of fibroblasts. Sulphathiazole, N1-benzoyl-sulphanilamide, or sulphanilamide in similar concentrations inhibit fibroblast growth. The above-mentioned five sulphonamides in concentrations up to 100 mgm. per 100 ml. have no apparent influence on fibroblast growth. In contrast, azochloramide in concentrations of 5 to 10 mgm. per 100 ml. inhibit growth.This publication has 2 references indexed in Scilit:
- In Vitro Action of Sulfonamides on ClostridiaJournal of Bacteriology, 1944
- THE INHIBITION OF THE BACTERIOSTATIC ACTION OF SULFONAMIDE DRUGS BY SUBSTANCES OF ANIMAL AND BACTERIAL ORIGINThe Journal of Experimental Medicine, 1940