Hematopoietic Growth Factors

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Abstract
THE hematopoietic growth factors are glycoprotein hormones that regulate the proliferation and differentiation of hematopoietic progenitor cells and the function of mature blood cells.1 2 3 The recognition that circulating factors regulate red-cell production was derived from the work of Carnot and Deflandre, who in 1906 induced erythrocytosis in normal rabbits by infusing them with plasma from anemic animals.4 Sixty years later, Pluznik and Sachs5 and Bradley and Metcalf6 developed the necessary semisolid culture systems to grow bone marrow progenitor cells in vitro. This led to the identification of hematopoietic growth factors, originally termed "colony-stimulating factors" because they stimulated the formation of . . .