Regulation of expression of the c‐Myc proto‐oncogene
- 1 January 1987
- Vol. 6 (1) , 28-32
- https://doi.org/10.1002/bies.950060108
Abstract
The c‐myc proto‐oncogene is normally subject to complex regulation at the transcriptional and post‐transcriptional levels in proliferating and differentiating cells. It is activated in response to growth stimuli and generally, though not always, repressed in response to differentiation signals. Abnormal, deregulated c‐myc expression is a common feature of numerous malignancies and occurs by a variety of molecular mechanisms which probably reflect the existence of multiple factors responsible for its normal control. Here, I provide a detailed summary of recent progress and current views on c‐myc gene regulation.Keywords
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