INHIBITION BY Cd2+, VERAPAMIL AND PAPAVERINE OF Ca2+‐INDUCED CONTRACTIONS IN ISOLATED CEREBRAL AND PERIPHERAL ARTERIES OF THE DOG

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Abstract
1 In helically cut strips of canine cerebral arteries exposed to Ca2+-free media and depolarized by K+, the addition of Ca2+ caused biphasic (transient and sustained) contractions, while in coronary and mesenteric arteries, the addition of Ca2+ produced a sustained contraction sometimes preceded by a slight transient contraction. 2 These Ca2+-induced contractions were attenuated by Cd2+ (5 to 100 μm) in a dose-dependent manner, the attenuation being greater in cerebral than in coronary and mesenteric arteries. The inhibitory effect of Cd2+ was prevented and partially reversed by 1 mm cysteine. 3 Verapamil and papaverine were also effective in attenuating the Ca2+-induced contractions in cerebral and peripheral arteries: susceptibility to verapamil was in the order, cerebral > coronary > mesenteric, while that to papaverine was in the order, cerebral = coronary > mesenteric. 4 It may be concluded that the agents that interfere with trans-membrane influxes of Ca2+ cause a greater relaxation in cerebral than in peripheral arteries, as is seen with papaverine, a non-specific vasodilator.