3He MRI in healthy volunteers: preliminary correlation with smoking history and lung volumes
Open Access
- 21 June 2000
- journal article
- research article
- Published by Wiley in NMR in Biomedicine
- Vol. 13 (4) , 182-189
- https://doi.org/10.1002/1099-1492(200006)13:4<182::aid-nbm642>3.0.co;2-n
Abstract
MRI with hyperpolarized helium‐3 (3He) provides high‐resolution imaging of ventilated airspaces. The first aim of this 3He‐study was to compare observations of localized signal defects in healthy smokers and non‐smokers. A second aim was to describe relationships between parameters of lung function, volume of inspired 3He and signal‐to‐noise ratio. With Ethics Committee approval and informed consent, 12 healthy volunteers (seven smokers and five non‐smokers) were studied. Imaging was performed in a 1.5 T scanner using a two‐dimensional FLASH sequence at 30V transmitter amplitude (TR/TE/α = 11 ms/4.2 ms/3He were inhaled from a microprocessor‐controlled delivery device and imaged during single breath‐holds. Images were evaluated visually, and scored using a prospectively defined ‘defect‐index’. Signal‐to‐noise ratio of the images were correlated with localization, 3He volumes and static lung volumes. Due to poor image quality studies of two smokers were not eligible for the evaluation. Smokers differed from non‐smokers in total number and size of defects: the ‘defect‐index’ of smokers ranged between 0.8 and 6.0 (median = 1.1), that of non‐smokers between 0.1 and 0.8 (median = 0.4). Intraindividually, an anteroposterior gradient of signal‐to‐noise ratio was apparent. Signal‐to‐noise ratio correlated with the estimated amount of hyperpolarization administered (r = 0.77), but not with static lung volumes. We conclude that 3He MRI is a sensitive measure to detect regional abnormalities in the distribution of ventilation in clinically healthy persons with normal pulmonary function tests. Copyright © 2000 John Wiley & Sons, Ltd.Keywords
This publication has 20 references indexed in Scilit:
- Quantification of Regional Intrapulmonary Oxygen Partial Pressure Evolution during Apnea by 3He MRIJournal of Magnetic Resonance, 1999
- Lung Air Spaces: MR Imaging Evaluation with Hyperpolarized3He GasRadiology, 1999
- MRI using hyperpolarized noble gasesEuropean Radiology, 1998
- Risk factors for bronchiolitis: Presentation of an on-going prospective clinical studyInflammation Research, 1997
- MR imaging and spectroscopy using hyperpolarized 129Xe gas: Preliminary human resultsMagnetic Resonance in Medicine, 1997
- Imaging of the lungs using 3he MRI: Preliminary clinical experience in 18 patients with and without lung diseaseJournal of Magnetic Resonance Imaging, 1997
- Cigarette smoking: CT and pathologic findings of associated pulmonary diseases.RadioGraphics, 1997
- Normal and abnormal pulmonary ventilation: visualization at hyperpolarized He-3 MR imaging.Radiology, 1996
- Human lung air spaces: potential for MR imaging with hyperpolarized He-3.Radiology, 1996
- Nuclear magnetic resonance imaging with hyperpolarised helium-3The Lancet, 1996