Hemolytic Anemia and Sulfhemoglobinemia Due to Phenacetin Abuse: A Case with Multivisceral Adverse Effects
- 1 January 1981
- journal article
- research article
- Published by Taylor & Francis in Clinical Toxicology
- Vol. 18 (4) , 493-499
- https://doi.org/10.3109/15563658108990274
Abstract
The authors report a case of recurrent sulfhemoglobinemia resulting from a chronic abuse of phenacetin. Cyanosis was accompanied by hemolytic anemia and numerous features of tissue aging. While phenacetin was found to be the oxidizing drug, no source of sulfur was identified. The origin of sulfhemoglobinemia in man is discussed and the possible role of intraerythrocytic glutathione is emphasized.Keywords
This publication has 20 references indexed in Scilit:
- Human β-mercaptopyruvate sulfurtransferase: Distribution in cellular compartments of blood and activity in erythrocytes from patients with hematological disordersClinica Chimica Acta; International Journal of Clinical Chemistry, 1978
- Sulfhaemoglobin. Absorption spectrum, millimolar extinction coefficient at λ = 620 nm, and interference with the determination of haemiglobin and of haemiglobincyanideClinica Chimica Acta; International Journal of Clinical Chemistry, 1977
- Effect of Charcoal-Broiled Beef on Phenacetin Metabolism in ManScience, 1976
- Isoelectrofocusing: A method of multiple applications for hemoglobin studiesClinica Chimica Acta; International Journal of Clinical Chemistry, 1976
- Tolerance to repeated phenacetin treatment in albino rats and guinea pigsToxicology and Applied Pharmacology, 1972
- ACETOPHENETIDIN-INDUCED METHEMOGLOBINEMIAAnnals of the New York Academy of Sciences, 1968
- Mechanism of formation of sulphhaemoglobinBiochimica et Biophysica Acta (BBA) - General Subjects, 1968
- PHENACETIN-INDUCED HÆMOLYTIC ANÆMIAThe Lancet, 1962
- SULPHÆMOGLOBINÆMIA AND GLUTATHIONEThe Lancet, 1960
- Sulfhemoglobinemia: A study of 62 clinical casesAmerican Heart Journal, 1951