Histone Deacetylase: A Regulator of Transcription
- 19 April 1996
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 272 (5260) , 371
- https://doi.org/10.1126/science.272.5260.371
Abstract
Histones are DNA binding proteins that bind without regard to the sequence of the DNA and help determine the three-dimensional organization of the chromatin into chromosomes. A paper in this week's issue (Taunton et al ., [p. 408][1]) reports the cloning of histone deacetylase, an ezyme that modifies histones by removing an acetyl group. In his Perspective, Wolffe explains how the action of this enzyme can lead to the regulation of the transcription of certain genes. [1]: /lookup/doi/10.1126/science.272.5260.408Keywords
This publication has 18 references indexed in Scilit:
- A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3pScience, 1996
- A proline-rich TGF-beta-responsive transcriptional activator interacts with histone H3.Genes & Development, 1995
- Modulation of Chromatin Folding by Histone AcetylationJournal of Biological Chemistry, 1995
- Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: A molecular model for the formation of heterochromatin in yeastCell, 1995
- Nucleosome Structural Changes Due to AcetylationJournal of Molecular Biology, 1994
- Transcriptional silencing in yeast is associated with reduced nucleosome acetylation.Genes & Development, 1993
- A positive role for histone acetylation in transcription factor access to nucleosomal DNACell, 1993
- Role of Nucleosomal Cores and Histone H1 in Regulation of Transcription by RNA Polymerase IIScience, 1991
- Yeast histone H4 N-terminal sequence is required for promoter activation in vivoCell, 1991
- The general affinity of lac repressor for E. coli DNA: Implications for gene regulation in procaryotes and eucaryotesCell, 1975