A gonadotrophin-releasing hormone (GnRH) antagonist inhibits GnRH- but not LH-induced meiosis in follicle-enclosed rat oocytes in vitro

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Abstract
Gonadotropin-releasing hormone (GnRH) can induce resumption of meiosis in follicle-enclosed rat oocytes. A GnRH antagonistic analog ([D-pGlul,D-Phe2-D-Trp3,6]LHRF) effectively abolished the stimulatory effect of a GnRH agonist on resumption of meiosis and lactate accumulation in isolated pre-ovulatory rat follicles, but had no effect on LH stimulation of these parameters. Although LH and GnRH can evoke a similar response, they apparently act through separate receptor sites and it is unlikely that GnRH mediates the effect of LH on meiosis or glycolysis.