SPURIOUS EFFECTS OF COMMERCIAL PREPARATIONS OF OXYTOCIN ON THE ISOLATED VAS DEFERENS OF THE RAT
Open Access
- 1 January 1981
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 72 (1) , 101-102
- https://doi.org/10.1111/j.1476-5381.1981.tb09111.x
Abstract
1 The inhibitory effect of a commercial preparation of oxytocin (Syntocinon) was studied on the isolated vas deferens of the rat. 2 The inhibition of contractions to agonists and to field stimulation obtained were mimicked by appropriate dilutions of chlorbutol, a preservative present in Syntocinon. 3 Preservative-free synthetic oxytocin had no inhibitory effect on the tissue and slightly potentiated contractions evoked by field stimulation. 4 It is concluded that inhibitory effects of Syntocinon on the vas deferens are due to chlorbutol, not oxytocin.Keywords
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