New Furoacridone Alkaloids from Tissue Culture ofRuta graveolens

Abstract
Two new furacridone alkaloids have been obtained from tissue culture of Ruta graveolens by DCCC of a crude dichloromethane extract and subsequent CC and TLC. On the basis of spectroscopic data their structures have been determined to be 1-hydroxyrutacridone epoxide (3) and its intramolecular substitution product (5, rutagravin); a third furoacridone has been identified as gravacridonol (4).

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