INDOCYANINE GREEN FLUORESCENCE ANGIOGRAPHY

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Abstract
Indocyanine green (ICG) fluorescence angiography was refined for use in laboratory and clinical investigations. In this modification of the Zeiss fundus camera all lenses excpet the aspherical objective lens were specially antireflection coated to increase light transmission in the spectral region around 800 nm. A 300 W indium iodide lamp continuous light source replaced the conventional Xe flash lamp. This light source produced a retinal irradiance of 265 mW restricting retinal exposure time to 11.9 s; 11.9 s was more than adequate to record passage of dye through the choroid. Spatial resolution of the fundus on the film was increased from 11.7-7.4 .mu.m. With these technical refinements the human choroidal circulation is viewed at 20 frames/s, which is adequate to document the very rapid movement of blood through the vasculature. ICG angiography may change the interpretations of choroidal circulatory based on fluorescein angiography. It clearly is an effective tool in laboratory investigations.