A double-blind trial of a zinc sulphate/citrate complex and tetracycline in the treatment of acne vulgaris

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Abstract
Forty-eight patients participated in a 3 mo. double-blind study comparing effects of orally administered zinc sulfate/citrate complex and tetracycline hydrochloride in acne vulgaris. Tetracycline reduced overall grade and number of non-inflamed lesions, papules and pustules by the 3rd mo. It reduced non-inflamed lesions and papules at the end of the 2nd mo. In contrast, Zn therapy only had a significant effect on the pustules at the 3rd mo. Tetracycline is superior to the Zn complex in relieving moderately severe acne.