Inhibition of nitric oxide synthesis leads to reduced parasitemia in murine Trypanosoma brucei infection
- 1 May 1994
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 62 (5) , 2135-2137
- https://doi.org/10.1128/iai.62.5.2135-2137.1994
Abstract
In murine Trypanosoma brucei infection, macrophage activation and nitric oxide (NO) production lead to suppressed splenic T-cell responses (J. Sternberg and F. McGuigan, Eur. J. Immunol. 22:2741-2744, 1992). In this study, evidence is presented that NO has no detectable trypanocidal activity under simulated in vivo conditions and that inhibition of NO production in vivo results in reduced parasitemia.Keywords
This publication has 14 references indexed in Scilit:
- Suppressor macrophages in African trypanosomiasis inhibit T cell proliferative responses by nitric oxide and prostaglandins.The Journal of Immunology, 1993
- Nitric oxide-mediated cytostatic activity on Trypanosoma brucei gambiense and Trypanosoma brucei bruceiExperimental Parasitology, 1992
- The role of the macrophage in induction of immunosuppression in Trypanosoma congolense-infected cattle.1991
- Nitric oxide: physiology, pathophysiology, and pharmacology.1991
- Regional haemodynamic changes during oral ingestion of NG‐monomethyl‐l‐arginine or NG‐nitro‐l‐arginine methyl ester in conscious Brattleboro ratsBritish Journal of Pharmacology, 1990
- Suppressive macrophages occurring in murine Trypanosoma brucei infection inhibit T‐cell responses in vivo and in vitroParasite Immunology, 1990
- Biosynthesis and Metabolism of Endothelium-Derived Nitric OxideAnnual Review of Pharmacology and Toxicology, 1990
- Dual role of macrophages in the suppression of interleukin 2 production and interleukin 2 receptor expression in trypanosome‐infected miceEuropean Journal of Immunology, 1989
- DISCONTINUOUS TRANSCRIPTION AND ANTIGENIC VARIATION IN TRYPANOSOMESAnnual Review of Biochemistry, 1986
- Macrophages as Mediators of Immunosuppression in Murine African TrypanosomiasisPublished by Springer Nature ,1985