In vitrotoxicity of trichothecenes on human haematopoietic progenitors
- 1 July 1994
- journal article
- research article
- Published by Taylor & Francis in Food Additives & Contaminants
- Vol. 11 (4) , 441-447
- https://doi.org/10.1080/02652039409374246
Abstract
The culture of human haematopoietic progenitors, Colony‐Forming‐Unit Granulocyte and Macrophage (CFU‐GM), has been performed in the presence of four trichothecenes, T‐2 toxin, HT‐2 toxin, diacetoxyscirpenol (DAS), and deoxynivalenol (DON). Our results showed that trichothecenes were cytotoxic for human haematopoietic progenitors. This work and the analysis of results described in the literature allowed us to propose that the haematologic lesions observed during human intoxication could be due to a destruction of haematopoietic progenitors such as granulocytic and macrophage colony‐forming cells.Keywords
This publication has 9 references indexed in Scilit:
- Relevance of In Vitro Studies of Drug-Induced AgranulocytosisDrug Safety, 1993
- In vitro effect of diacetoxyscirpenol and deoxynivalenol on microbicidal activity of murine peritoneal macrophagesMycopathologia, 1992
- T-2 toxin effect on bacterial infection and leukocyte functionsToxicology and Applied Pharmacology, 1984
- The effects of T-2 toxin on alveolar macrophage function in vitroEnvironmental Research, 1984
- Toxicity of T-2 toxin, a Fusarium mycotoxin, to alveolar macrophages in vitroEnvironmental Research, 1983
- TOXICOLOGICAL APPROACHES TO THE METABOLITES OF FUSARIA. XIII. HEMATOLOGICAL CHANGES IN MICE BY A SINGLE AND REPEATED ADMINISTRATIONS OF TRICHOTHECENESThe Journal of Toxicological Sciences, 1978
- Heterogeneity in human neutrophil, macrophage and eosinophil progenitor cells demonstrated by velocity sedimentation separationBlood, 1977
- A comparison of granulopoiesis in culture from blood and marrow cells of nonleukemic individuals and patients with acute leukemiaBlood, 1976
- Human bone marrow colony growth in agar‐gelJournal of Cellular Physiology, 1970