A potent, simple derivative of an analog of the CC-1065 alkylation subunit
- 31 December 1991
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 1 (1) , 55-58
- https://doi.org/10.1016/s0960-894x(01)81090-8
Abstract
No abstract availableKeywords
This publication has 15 references indexed in Scilit:
- A demonstration of the intrinsic importance of stabilizing hydrophobic binding and non-convalent van der waals contacts dominant in the non-covalent CC-1065/B-DNA bindingChemico-Biological Interactions, 1990
- Duocarmycin-pyrindamycin DNA alkylation properties and identification, synthesis, and evaluation of agents incorporating the pharmacophore of the duocarmycin-pyrindamycin alkylation subunit. Identification of the CC-1065 duocarmycin common pharmacophoreJournal of the American Chemical Society, 1990
- Synthesis of N-(phenylsulfonyl)-CI, N-((tert-butyloxy)carbonyl)-CI, CI-CDPI1, and CI-CDPI2: CC-1065 functional analog incorporating the parent 1,2,7,71-tetrahydrocycloprop[1,2-c]indol-4-one (CI) left-hand subunitJournal of the American Chemical Society, 1990
- Sequence specificity of DNA alkylation by the unnatural enantiomer of CC-1065 and its synthetic analogsJournal of the American Chemical Society, 1990
- Synthesis and evaluation of aborted and extended CC-1065 functional analogs: (+)- and (-)-CPI-PDE-I1, (+)- and (-)-CPI-CDPI1, and (.+-.)-, (+)-, and (-)-CPI-CDPI3. Preparation of key partial structures and definition of an additional functional role of the CC-1065 central and right-hand subunitsJournal of the American Chemical Society, 1990
- Total synthesis and evaluation of (.+-.)-N-(tert-butoxycarbonyl)-CBI, (.+-.)-CBI-CDPI1, and (.+-.)-CBI-CDPI2: CC-1065 functional agents incorporating the equivalent 1,2,9,9a-tetrahydrocyclopropa[1,2-c]benz[1,2-e]indol-4-one (CBI) left-hand subunitJournal of the American Chemical Society, 1989
- Total synthesis of (.+-.)-N-(phenylsulfonyl)- and (.+-.)-N-(tert-butyloxycarbonyl)-CI, (.+-.)-CI-CDPI1, and (.+-.)-CI-CDPI2: CC-1065 functional analogs incorporating the parent 1,2,7,7a-tetrahydrocycloprop[1,2-c]indol-4-one (CI) left-hand subunitThe Journal of Organic Chemistry, 1989
- Sequence selectivity of DNA covalent modificationChemical Research in Toxicology, 1988
- Total synthesis of (.+-.)-N2-(phenylsulfonyl)-CPI, (.+-.)-CC-1065, (+)-CC-1065, ent-(-)-CC-1065, and the precise, functional agents (.+-.)-CPI-CDPI2, (+)-CPI-CDPI2, and (-)-CPI-CDPI2 [(.+-.)-(3bR*,4aS*)-, (+)-(3bR,4aS)-, and (-)-(3bS,4aR)-deoxy-CC-1065]Journal of the American Chemical Society, 1988
- Stereoelectronic factors influencing the biological activity and DNA interaction of synthetic antitumor agents modeled on CC-1065Journal of Medicinal Chemistry, 1988