Circadian Periodicity in Susceptibility to Lidocaine Hydrochloride
- 7 April 1967
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 156 (3771) , 100-102
- https://doi.org/10.1126/science.156.3771.100
Abstract
Separate groups of mice standardized in an alternating 12-hour-light,12-hour-dark regimen were treated with lidocaine hydrochloride every 3 hours over a 24-hour period. The results indicate a quantitative circadian periodicity with maximal convulsant activity at 2100 hours which was approximately a fourteen fold increase over the values observed at 1500 hours.This publication has 8 references indexed in Scilit:
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