STUDIES ON SUPRARENAL INSUFFICIENCY

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Abstract
The lethal intraperitoneal dose of histamine acid phosphate for normal albino rats is more than 100 mgm. per 100 gm. of body weight. The minimal lethal dose for doubly suprarenalectomized rats is about 7 mgm. per 100 gm. This increased susceptibility is constant, at least up to 5 mos. after operation. Suprarenalectomized rats having gross accessory cortical tissue or autoplastic cortical transplants are as susceptible to histamine as rats having no cortical tissue and suffering from cortical insufficiency. The presence of accessory chromaffin tissue appears to protect from the fatal effects of doses of histamine, which are lethal for rats having no such tissue. Intraperitoneal injections of small amounts of adrenalin chloride solution afford partial or complete protection from the fatal effects of lethal doses of histamine. It is concluded that the increased susceptibility to histamine is largely due to the lack of medullary tissue, and that increased susceptibility to histamine is not a test for cortical insufficiency.