THE HEMODYNAMIC ACTION OF MINIMAL EFFECTIVE DOSES OF EPINEPHRIN IN THE UNANESTHETIZED DOG

Abstract
Minimal effective doses of epinephrin in unanesthetized dogs in all instances produced pressor responses. Blood pressure was recorded by a carotid artery transplant made 1-2 days prior to the experiments. The minimal effective dose of epinephrin in the unanesthetized animals was less than 0.2[long dash]0.4 cc. of [1:1,000,000 solution of adrenalin per kgm. per min., or but 50-100% greater than the estimated average output of epinephrin by the adrenals.

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