Steroidal .alpha.-methylene .delta.-lactones as potential antitumor agents
- 1 January 1980
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 23 (1) , 90-92
- https://doi.org/10.1021/jm00175a019
Abstract
Four novel steroidal .alpha.-methylene .delta.-lactones were synthesized and are active against human nasopharyngeal carcinoma (KB) cells in culture. The syntheses involved the use of known .alpha.-methylenation procedures. A lactone was directly methylenated by reaction with CH2O/KOH or Et2NH/CH2O/Et2NH .cntdot. HCl. The formation of a cysteine adduct with the .alpha.-methylene lactone is reported.This publication has 3 references indexed in Scilit:
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