Imiquimod Treatment of Anal Intraepithelial Neoplasia in HIV-Positive Men
Open Access
- 1 November 2006
- journal article
- clinical trial
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 142 (11) , 1438-1444
- https://doi.org/10.1001/archderm.142.11.1438
Abstract
Like cervical cancer, anal cancer is causally linked to persistent infection with high-risk human papillomavirus (HPV) types such as HPV-16 or HPV-18.1-3 In human immunodeficiency virus (HIV)-positive men who have sex with men (MSM), anal HPV prevalence is approximately 90%, and infections with multiple HPV types are common.4-6 Consequently, HIV-positive MSM have a strongly increased risk for anal cancer and its precursor, anal intraepithelial neoplasia (AIN). Despite highly active antiretroviral therapy (HAART), the incidence and prevalence of AIN and anal cancer have not decreased in HIV-positive MSM.6-8 In a recent study, 52% of HIV-positive men presented with advanced AIN.6Keywords
This publication has 28 references indexed in Scilit:
- Anal intraepithelial neoplasia in the highly active antiretroviral therapy era among HIV-positive men who have sex with menAIDS, 2005
- Detection of Human Papillomavirus (HPV) 16-Specific CD4+ T-cell Immunity in Patients with Persistent HPV16-Induced Vulvar Intraepithelial Neoplasia in Relation to Clinical Impact of Imiquimod TreatmentClinical Cancer Research, 2005
- The Role of Toll-like Receptors in the Pathogenesis and Treatment of Dermatological DiseaseJournal of Investigative Dermatology, 2005
- Human papillomavirus anogenital disease in HIV-infected individualsDermatologic Therapy, 2005
- Topical Immunomodulation in Dermatology: Potential of Toll-like Receptor AgonistsDermatologic Surgery, 2004
- High Prevalence of Anal Squamous Intraepithelial Lesions in HIV-Positive Men Despite the Use of Highly Active Antiretroviral TherapySexually Transmitted Diseases, 2004
- Topical immunomodulators—progress towards treating inflammation, infection, and cancerThe Lancet Infectious Diseases, 2001
- A study of anal intraepithelial neoplasia in HIV positive homosexual menSexually Transmitted Infections, 1999
- Human Papillomavirus Infection and Anogenital Neoplasia in Human Immunodeficiency Virus-Positive Men and WomenJNCI Monographs, 1998
- Prevalence and Risk Factors for Human Papillomavirus Infection of the Anal Canal in Human Immunodeficiency Virus (HIV)‐Positive and HIV‐Negative Homosexual MenThe Journal of Infectious Diseases, 1998