Divergent action of transforming growth factor ? on DNA synthesis in human foetal liver cells
- 1 November 1986
- journal article
- research article
- Published by Wiley in Cell Biology International Reports
- Vol. 10 (11) , 855-860
- https://doi.org/10.1016/0309-1651(86)90102-5
Abstract
Purified human transforming growth factor .beta. (TGF.beta.) was found to be a potent inhibitor of DNA synthesis in human foetal hepatocytes. Half-maximal inhibition occurred at 0.5-1 pM and was reversible, with an increase in DNA synthesis within 24 h following removal of TGF.beta.. By contrast, in the same cultures, "fibroblast-like" non-hepatocytes retained the ability to synthesize DNA in the presence of up to 200 fold higher doses of TGF.beta.. This differential response to TGF.beta. suggests that it may act as an important cell growth regulator in the human foetal liver.This publication has 9 references indexed in Scilit:
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