Cerebral Edema in Severe Diabetic Ketoacidosis

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Abstract
To the Editor: In the March 23 issue of the Journal Young and Bradley described 2 children with diabetic ketoacidosis who died despite apparently appropriate therapy. The finding of cerebral edema may have been secondary to some ill understood toxic concomitant of the ketoacidosis. However, it is conceivable that the pathogenesis of the cerebral edema was similar to that which can follow the rapid removal of urea during hemodialysis of azotemic patients, reported by Kennedy et al. in their study, "The Pathogenesis and Prevention of Cerebral Dysfunction during Dialysis (Lancet 1:790–793, 1964).The concentration of glucose in the cerebral . . .

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