CYCLIC ADENOSINE 3′, 5′-MONOPHOSPHATE AND THE MECHANISM OF ACTION OF THREE COMMON ANTI-INFLAMMATORY DRUGS
- 1 February 1979
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 65 (2) , 163-165
- https://doi.org/10.1111/j.1476-5381.1979.tb07814.x
Abstract
1 The effects of indomethacin, dexamethasone and colchicine on cyclic adenosine 3', 5'-monophosphate (cyclic AMP) concentration in leucocytes during a crystal-induced pleurisy in rats were studied. 2 Each of the drugs significantly increased leucocyte cyclic AMP content within 3 h of the injection of crystals. 3 By 6 h, leucocyte cyclic AMP levels returning toward control levels and could not be sustained at the higher level by an additional administration of the respective anti-inflammatory drug.Keywords
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