Changing Fear: The Neurocircuitry of Emotion Regulation
Top Cited Papers
- 26 August 2009
- journal article
- review article
- Published by Springer Nature in Neuropsychopharmacology
- Vol. 35 (1) , 136-146
- https://doi.org/10.1038/npp.2009.121
Abstract
The ability to alter emotional responses as circumstances change is a critical component of normal adaptive behavior and is often impaired in psychological disorders. In this review, we discuss four emotional regulation techniques that have been investigated as means to control fear: extinction, cognitive regulation, active coping, and reconsolidation. For each technique, we review what is known about the underlying neural systems, combining findings from animal models and human neuroscience. The current evidence suggests that these different means of regulating fear depend on both overlapping and distinct components of a fear circuitry.Keywords
This publication has 101 references indexed in Scilit:
- Extinction-Reconsolidation Boundaries: Key to Persistent Attenuation of Fear MemoriesScience, 2009
- Avoiding negative outcomes: tracking the mechanisms of avoidance learning in humans during fear conditioningFrontiers in Behavioral Neuroscience, 2009
- Helping behaviour and regard for others in capuchin monkeys ( Cebus apella )Biology Letters, 2008
- Prefrontal-Subcortical Pathways Mediating Successful Emotion RegulationNeuron, 2008
- Neural Circuitry Underlying the Regulation of Conditioned Fear and Its Relation to ExtinctionNeuron, 2008
- Neural Mechanisms of Extinction Learning and RetrievalNeuropsychopharmacology, 2007
- Hippocampal regulation of context-dependent neuronal activity in the lateral amygdalaLearning & Memory, 2007
- Context-Dependent Human Extinction Memory Is Mediated by a Ventromedial Prefrontal and Hippocampal NetworkJournal of Neuroscience, 2006
- The Promise of Extinction Research for the Prevention and Treatment of Anxiety DisordersBiological Psychiatry, 2006
- Amygdala BDNF signaling is required for consolidation but not encoding of extinctionNature Neuroscience, 2006